Aspects of the pseudo Chiral Magnetic Effect in 2D Weyl-Dirac Matter

A connection is established between the continuum limit of the low-energy tight-binding description of graphene immersed in an in-plane magnetic field and the Chiral Magnetic Effect in Quantum Chromodynamics. A combination of mass gaps that explicitly breaks the equivalence of the Dirac cones, favoring an imbalance of pseudo-chiralities, is the essential ingredient to generate a non-dissipative electric current along the external field. Currents, number densities and condensates generated from this setup are investigated for different hierarchies of the energy scales involved.Comment: 12 pages, 8 figures. Several text improvements. Accepted for publication in European Physical Journal

Satisfacción de los clientes del servicio de Claro TV Satelital atendidos por la sucursal de ALFA S.A en los departamentos de Estelí y Madriz en el año 2016

Esta investigación evalúa la satisfacción de los clientes del servicio de Claro TV Satelital atendidos por el distribuidor autorizado Alfa S.A. en los departamentos de Estelí y Madriz. La investigación es de carácter cuantitativo, en donde se aplicaron 254 encuestas a usuarios del servicio en ambos departamentos, para apoyar el análisis se realizaron tres tipos de entrevistas semi-estructuradas dirigidas a clientes, gerente administrativo del distribuidor y supervisora de Claro. En este estudio se proponen tres estrategias para solucionar las debilidades de la empresa: asignar un responsable de supervisión de ventas para cada departamento, crear un sistema de call center para verificar la calidad y la satisfacción de los clientes, por último, la estrategia que el estudio considera de mayor importancia es establecer un focalizado para ofrecer un precio más bajo que la competencia, que permita aumentar la competitividad y la satisfacción de los usuarios

The Wall: A mobile app to identify and store social events from a digital image using computer vision

Social events, promoted in print media using posters, flyers and banners often fail to attract an audience because we frequently forget the details of the event when we pass-by the promotion on the street. Smaller venues or artists often rely on low-cost, street-level marketing campaigns in areas of high foot traffic areas to develop interest in an event. These venues or artist are often without a budget for online marketing or have a target demographic outside the typical Social Media consumer which makes attracting an audience difficult. This project aimed to solve the problem of storing and reminding the user of upcoming events, advertised in print media, by developing a mobile app to automatically identify and event information from an image taken by the user. The project is an N-tier system comprising: a front-end using AngularJS, Ionic and Cordova; a cloud Firebase database to store the user\u27s registration and logon credentials; Google Vision API to automatically segment and identify event information and the Google Calendar API to store and remind the user of upcoming events. The project was managed using the Agile Development methodology Scrum. The challenge of this project was in developing a solution to automatically and reliably identify event information from print media which often contains a wide variety of layouts, orientations, font types, colours and contrast variations between the information and any graphics present. In addition, the solution needed to understand the semantics of the text relating to the event name and location. The development frameworks and APIs chosen were unfamiliar to the team but were used because of their technical suitability and their ongoing and increasing popularity in the industry. Functional testing was based on a set of over 50 test images. Testing concluded that the solution retrieves date and time information consistently, however, more work is required to successfully segment and recognise event location and title. User Experience (UX) was measured in a cross-sectional survey of 75 participants. The results were positive and are discussed here

Pseudoestenosis mitral de rápida evolución por mixoma auricular

Secondary cardiac tumours are 20-40 times more frequent than primary tumours. Around 80% of primary tumours are benign, and more than 50% of these are myxomas. Within the myxomas, 80% arises at the level of the left atrium, and its form of presentation is very varied, being able to cause obstruction of the left ventricle entrance tract, arrhythmias and embolic phenomenaLos tumores cardiacos secundarios son 20-40 veces más frecuentes que los primarios. En torno al 80 % de los tumores primarios son benignos, y más del 50% de estos son mixomas. Dentro de los mixomas, el 80% se origina a nivel de aurícula izquierda, y su forma de presentación es muy variada, pudiendo provocar obstrucción del tracto de entrada del ventrículo izquierdo, arritmias y fenómenos embólicos

The induction of natural competence adapts staphylococcal metabolism to infection

A central question concerning natural competence is why orthologs of competence genes are conserved in non-competent bacterial species, suggesting they have a role other than in transformation. Here we show that competence induction in the human pathogen Staphylococcus aureus occurs in response to ROS and host defenses that compromise bacterial respiration during infection. Bacteria cope with reduced respiration by obtaining energy through fermentation instead. Since fermentation is energetically less efficient than respiration, the energy supply must be assured by increasing the glycolytic flux. The induction of natural competence increases the rate of glycolysis in bacteria that are unable to respire via upregulation of DNA- and glucose-uptake systems. A competent-defective mutant showed no such increase in glycolysis, which negatively affects its survival in both mouse and Galleria infection models. Natural competence foster genetic variability and provides S. aureus with additional nutritional and metabolic possibilities, allowing it to proliferate during infection

Clinical Utility of Ghrelin-O-Acyltransferase (GOAT) Enzyme as a Diagnostic Tool and Potential Therapeutic Target in Prostate Cancer

Recent data suggested that plasma Ghrelin O-Acyl Transferase enzyme (GOAT) levels could represent a new diagnostic biomarker for prostate cancer (PCa). In this study, we aimed to explore the diagnostic and prognostic/aggressiveness capacity of GOAT in urine, as well as to interrogate its putative pathophysiological role in PCa. We analysed urine/plasma levels of GOAT in a cohort of 993 patients. In vitro (i.e., cell-proliferation) and in vivo (tumor-growth in a xenograft-model) approaches were performed in response to the modulation of GOAT expression/activity in PCa cells. Our results demonstrate that plasma and urine GOAT levels were significantly elevated in PCa patients compared to controls. Remarkably, GOAT significantly outperformed PSA in the diagnosis of PCa and significant PCa in patients with PSA levels ranging from 3 to 10 ng/mL (the so-called PSA grey-zone). Additionally, urine GOAT levels were associated to clinical (e.g., Gleason-score, PSA levels) and molecular (e.g., CDK2/CDK6/CDKN2A expression) aggressiveness parameters. Indeed, GOAT overexpression increased, while its silencing/blockade decreased cell-proliferation in PCa cells. Moreover, xenograft tumors derived from GOAT-overexpressing PCa (DU145) cells were significantly higher than those derived from the mock-overexpressing cells. Altogether, our results demonstrate that GOAT could be used as a diagnostic and aggressiveness marker in urine and a therapeutic target in PCa

Del color de los ojos al interior del genoma. Nuevas tecnologías aplicadas a la educación: una experiencia en la enseñanza de la Genética

Depto. de Genética, Fisiología y MicrobiologíaFac. de Ciencias BiológicasFALSEsubmitte

Experiencias de Innovación docente en los Estudios Jurídicos: una visión práctica

Esta publicación se enmarca dentro de las actividades del Grupo de Investigación de la Universidad de Extremadura Fiscalitas & Iuris.Este trabajo surge con el objetivo principal de dar visibilidad y publicidad a las nuevas técnicas docentes en el seno de la Facultad de Derecho de la UEx. Como se sabe, se ha producido un innegable y significativo avance en el uso de nuevas técnicas docentes y también de las TICs aplicadas a la docencia en la Facultad de Derecho, no obstante, aún es necesario profundizar en el uso de las mismas y extenderlas entre todos los miembros del claustro de profesores, y fundamentalmente entre aquellos que llevan más años ejerciendo la docencia a través de la colaboración y la coordinación con los profesores noveles, que son quienes principalmente se sirven en mayor medida de tales instrumentos docentes. De otra parte, también era necesario que los docentes más experimentados pudieran encontrar un foro en el que transmitir y compartir con los noveles cuales son las técnicas e instrumentos docentes que ellos han venido utilizando durante el ejercicio de su magisterio, de modo que, en el marco de una relación sinalagmática, se produjera una interacción entre uno u otro grupo de docentes, a fin de fomentar el necesario debate y el intercambio de experiencias e instrumentos docentes, y en su caso el desarrollo y perfeccionamiento de los mismos; algo que hemos pretendido realizar con este trabajo, y que en buena medida hemos logrado. Las finalidades y objetivos concretos que perseguíamos, en atención a la situación expuesta eran fundamentalmente tres: • En primer lugar, la implementación de un proyecto de innovación docente integrado por una diversidad de actividades coordinadas, cada uno de ellas bajo la directa coordinación de un profesor o profesora de la UEx, aplicado a una o varias asignaturas impartidas en la Facultad de Derecho. • En segundo lugar, el establecimiento en la Facultad de Derecho de un foro de coordinación e intercambio de buenas prácticas docentes sobre la base de cada uno de las actividades coordinadas, en el que pudieran participar profesores noveles y veteranos. Para ello se desarrolló espacio virtual de innovación docente en estudios jurídicos, a través del Campus Virtual de la UEx, en el que los Profesores noveles y veteranos pudieron y puede compartir recursos e informaciones sobre prácticas de innovación. • Y, en tercer lugar, la difusión y consolidación de instrumentos de innovación docente directamente aplicadas a la docencia de los estudios jurídicos, mediante la transferencia de los resultados y la publicación de los mismos; a fin de que esta transferencia sirva de base a futuras profundizaciones en el campo de la innovación docente en los estudios jurídicos.Proyecto “Desarrollo, profundización e intercambio de buenas prácticas de innovación docente en la Facultad de Derecho” (UEx 2015-2016

The interplay between functioning problems and symptoms in first episode of psychosis: an approach from network analysis

The relationship between psychotic symptoms and global measures of functioning has been widely studied. No previous study has assessed so far the interplay between specific clinical symptoms and particular areas of functioning in first-episode psychosis (FEP) using network analysis methods. A total of 191 patients with FEP (age 24.45 ± 6.28 years, 64.9% male) participating in an observational and longitudinal study (AGES-CM) comprised the study sample. Functioning problems were assessed with the WHO Disability Assessment Schedule (WHODAS), whereas the Positive and Negative Syndrome Scale (PANSS) was used to assess symptom severity. Network analysis were conducted with the aim of analysing the patterns of relationships between the different dimensions of functioning and PANSS symptoms and factors at baseline. According to our results, the most important nodes were “conceptual disorganization”, “emotional withdrawal”, “lack of spontaneity and flow of conversation”, “delusions”, “unusual thought content”, “dealing with strangers” and “poor rapport”. Our findings suggest that these symptoms and functioning dimensions should be prioritized in the clinical assessment and management of patients with FEP. These areas may also become targets of future early intervention strategies, so as to improve quality of life in this populationThis work was supported by the Madrid Regional Government (R&D activities in Biomedicine (grant number S2017/BMD-3740 - AGES-CM 2-CM)) and Structural Funds of the European Union. Ana Izquierdo’s work is supported by the PFIS predoctoral program (FI17/00138) from the Instituto de Salud Carlos III (Spain) and co-funded by the European Union (ERDF/ESF, "A way to make Europe”/ “Investing in your future”) and The Biomedical Research Foundation of La Princesa University Hospital. Angela Ib´a˜nez thanks the support of CIBERSAM and of the Spanish Ministry of Science, Innovation and Universities. Instituto de Salud Carlos III (PI16/00834 and PI19/01295) co-financed by ERDF Funds from the European Commission. Covadonga M. Díaz-Caneja holds a Juan Rod´es Grant from Instituto de Salud Carlos III (JR19/00024). Celso Arango was supported by the Spanish Ministry of Science and Innovation. Instituto de Salud Carlos III (SAM16PE07CP1, PI16/02012, PI19/ 024), co-financed by ERDF Funds from the European Commission, “A way of making Europe”, CIBERSAM. Madrid Regional Government (B2017/BMD-3740 AGES-CM-2), European Union Structural Funds. European Union Seventh Framework Program under grant agreements FP7-4-HEALTH-2009-2.2.1-2-241909 (Project EU-GEI), FP7- HEALTH- 2013-2.2.1-2-603196 (Project PSYSCAN) and FP7- HEALTH-2013- 2.2.1-2-602478 (Project METSY); and European Union H2020 Program under the Innovative Medicines Initiative 2 Joint Undertaking (grant agreement No 115916, Project PRISM, and grant agreement No 777394, Project AIMS-2-TRIALS), Fundaci´on Familia Alonso, Fundaci´on Alicia Koplowitz and Fundaci´on Mutua Madrile˜n